目的 开发碳青霉烯类药物的f%T>MIC计算模型,结合浓度结果调整用药方案。方法 推导多次静脉输注给药达稳后全周期内药物浓度变化药动学公式,运用EXCEL软件编制f%T>MIC计算器,结合达稳后用药前0.5、3 h的血药浓度评价ICU患者中亚胺培南和美罗培南的药效达标情况。结果 该计算模型可用于给药方案f%T>MIC达标评价及确定优化方案,已用于确定107例ICU患者使用亚胺培南或美罗培南治疗期间的f%T>MIC水平。结论 本试验的计算模型能够为给药方案的评价及优化提供依据,并可推广用于其他时间依赖型抗菌药物。
Abstract
OBJECTIVE To develop the f%T>MIC computing model of carbapenems and adjust dose strategy based on the drug concentrations. METHODS Pharmacokinetic equations within one time interval were deduced at steady state after multiple intravenous infusion. f%T>MIC calculator was compiled using EXCEL software and used for evaluation of antibiotic effect based on the concentrations at 0.5 and 3 h before administration of imipenem or meropenem at steady state. RESULTS The calculation model can be used for f%T>MIC evaluation and dosage optimization. The model was used to determine f%T>MIC level of 107 ICU patients receiving imipenem or meropenem treatment. CONCLUSION The present calculation model can provide a basis for the evaluation and optimization of dosage strategy,and it can be applied to other time-dependent antibiotics.
关键词
碳青霉烯类 /
时间依赖型 /
f%T＞MIC /
重症
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Key words
carbapenem /
time-dependent antibiotics /
f%T＞MIC /
critical care
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中图分类号：
R969.3
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参考文献
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脚注
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基金
国家自然科学基金青年项目资助(81302843);中日友好医院科研基金项目资助(2014-4-QN-31)
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